肝素类抗凝药物作用机制及发展.pptVIP

如何理解戊糖的抗栓机制 常用抗凝药物抗凝特性 普通肝素： 有相似的抗Xa与IIa活性 低分子肝素：法安明 克塞 速碧林 抗Xa大于IIa活性 戊糖：磺达肝素钠 只有抗Xa活性 水蛭素类：比伐卢丁 只有抗IIa活性 谢谢 * The manufacturing process for heparin remains much the same today as in the early 1900’s, utilizing a number of extraction and filtration processes, as described in the recipe on this slide. Bivalirudin, however, is manufactured using a modern, synthetic process. The molecule is synthesized using an entirely chemical process, followed by a chromatographic purification and final isolation by lyophilization. * Dr. Irving S. Wright, the first doct