03抗体及其基因、B细胞发育(English version).ppt

IgM 3.Biological Activities ①pioneer antibody against infections the strongest anti- bacterial effect (500~1000×IgG) anti-viral effect anti-toxic effect Opsonization (the strongest ) Fixation complement Neutralizing virus toxin Agglutinating microbes Mediating ADCC ②mediating hypersensitivity II,III ③ mediating autoimmunity IgA IgA dimer 2.properties: 1)the 2nd most common Ig (serum IgA) 2)the major Ig in secretions. (secretory IgA,sIgA.5-15g/d) Saliva, tears, breast milk, nasal mucus secretions, bronchial secretions, vaginal secretions, prostatic fluid, mucous secretions of small intestine. SC J chain IgA 3) sIgA :transferred to the newborn through colostrum(初乳） sIgA 3.Biological Activities ①the important antibody against mucosal infections Preventing attachment of pathogens to mucosal cells. Neutralizing virus toxin Salmonella, Vibrio Cholerae, Neisseria Gonorrhoeae Reovirus.Pilio,influenza anti-bacterial effect anti-viral effect anti-toxic effect IgE Structure of IgE molecule IgE 2.properties 1)the least common Ig 2)binds to basophils mast cells (Fc?R) Cytophilic Ab:IgE binds very tightly to Fc recrpters on Basophils mast cells even before interacting with Ag. 3)not fix complement IgE 3.Biological Activities ①involved in allergic reactions ( hypersensitivity I) Binding to basophils mast cells Resulting in the release of various pharmaco- logical mediators Eosinophils have FcR for IgE,binding of Eosinophils ,to IgE- coated helminths (蠕虫）results in killing of the parasite. ②anti-parasitic i