RocheTBIL和DBIL项目介绍-培训课件.pptVIP

Trans-esterification of either one or both acid function Structure of the unconjugated bilirubin Non polar molecule, internal H-bonding makes it only slightly water soluble - the free bilirubin is complexed to proteins ,this makes it more soluble - Non-covalent bond to ALB is needed the allow the transport of bilirubin in the blood DELTA bilirubin all the conjugated bilirubins mBc + dBC + deltaBc can be excreted in the bile * * * * TBIL slide is based on Diazo reaction. Dyphylline = accelerator Bu, Bc and Bd react to form azobilirubin Buffer layer - azobilirubin is pink in colou