肝性脑病患者给予注射液门冬氨酸鸟氨酸及乳果糖联合治疗效果评价.docVIP

肝性脑病患者给予注射液门冬氨酸鸟氨酸及乳果糖联合治疗效果评价 　　【摘要】 目的：研究门冬氨酸鸟氨酸注射液联合乳果糖治疗肝性脑病（HE）的临床效果。方法：将笔者所在医院收治的46例HE患者随机分为观察组和对照组，各23例，对照组患者在常规治疗的基础上给予乳果糖溶液口服或灌肠治疗，观察组患者在对照组基础上加用门冬氨酸鸟氨酸静脉滴注治疗，两组患者均治疗14 d。记录两组患者治疗前后血氨水平、肝功能指标变化及HE分期改变，比较两组患者治疗总有效率及不良反应发生率。结果：两组患者治疗后血氨水平及肝功能指标均较治疗前显著改善，差异有统计学意义（P0.05），治疗后观察组HE分期改善情况显著优于对照组，差异有统计学意义（P0.05）。结论：门冬氨酸鸟氨酸注射液和乳果糖联合治疗肝性脑病效果显著，安全性好，值得推广应用 【关键词】 肝性脑病； 门冬氨酸鸟氨酸； 乳果糖 doi：10.14033/j.cnki.cfmr.2017.9.002 文献标识码 A 文章编号 1674-6805（2017）09-0003-03 【Abstract】 Objective：To study the clinical effect of L-ornithine-L-aspartate injection combined with Lactulose in the treatment of hepatic encephalopathy（HE）.Method：In our hospital，46 cases of HE patients were randomly divided into observation group and control group with 23 cases in each group.The control group were treated with Lactulose oral or enema treatment on the basis of conventional therapy，patients in the observation group used L-ornithine-L-aspartate intravenous infusion therapy based on the control group.The patients were treated for 14 d.Before and after treatment，the blood ammonia level，liver function index and HE stage were recorded and compared between the two groups.The total effective rate and adverse reaction rate were compared between the two groups.Result：Patients of the two groups after treatment，the level of blood ammonia and liver function indexes were significantly improved compared with before treatment（P0.05），after treatment，HE stage in the observation group improved significantly compared with control group（P0.05）.Conclusion：L-ornithine-L-aspartate injection combined with Lactulose has significant effect on hepatic encephalopathy，good safety，it is worthy of popularization and application. 【Key words】 Hepatic encephalopathy； L-ornithine-L-aspartate； Lactulose First-authors address：Yubei District Chongqing Peoples Hospital，Chongqing 401120，China 肝性?X病（HE）又称肝性昏迷，是由急、慢性肝功能衰竭或门体分流导致代谢紊乱，进而发展成的中枢神经系统功能失调综合征，患者常表现为行为异常、精神错乱和昏迷[1]。HE的发病具有隐匿性，严重威胁患者生命安全，死亡率很高。目前临床上治疗HE的主要方法是降低患者血氨水平