LTP讲座医.pptVIP

LTP原理及其记录;华中科技大学同济医学院药理系陈建国教授实验室;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;代表性研究成果;Ma LQ, Liu C, Wang ?F, Xie? N, Gu? J, Fu H, Wang JH, Cai ?F, Liu? J and Chen JG, Activation of phosphatidylinositol-linked novel D1 dopamine receptors inhibits high voltage activated Ca2+ currents in primary cultured striatal neurons. Journal of Neurophysiology, 101(5):2230-8. Zhang WT, Ruan JL, Wu PF, Jiang FC, Zhang LN, Fang W, Chen XL, Wang Y, Cao BS, Chen GY, Zhu YJ, Gu J, Chen JG. Design, synthesis, and cytoprotective effect of 2-Aminothiazole Analogs as potent poly (ADP-ribose) polymerase-1 inhibitors. Journal of Medicinal Chemistry 52(3): 718-25. 2009 Liu J, Wang F, Huang C, Long LH, Wu WN, Cai F, Wang JH, Ma LQ, Chen JG. Activation of Phosphatidylinositol-linked Novel D(1) Dopamine Receptor Contributes to the Calcium Mobilization in Cultured Rat Prefrontal Cortical Astrocytes. Cell Mol Neurobiol. 29(3):317-28. 2009 Long LH, Liu J, Liu RL, Wang F, Hu ZL, Xie N, Fu H, Chen JG. Differential Effects of Methionine and Cysteine Oxidation on [Ca(2+)] (i) in Cultured Hippocampal Neurons. Cell Mol Neurobiol. 29(1):7-15, 2009 Cai F, Wang F, Lin FK, Liu C, Ma LQ, Liu J, Wu WN, Wang W, Wang JH, Chen JG. Redox modulation of long-term potentiation in the hippocampus via regulation of the glycogen synthase kinase-3beta pathway. Free Radic Biol Med. 45(7):964-70, 2008. Wang JH, Wang F, Yang MJ, Yu DF, Wu WN, Liu J, Ma LQ, Cai F, Chen JG. Leptin regulated calcium channels of neuropeptide Y and proopiomelanocortin neurons by activation of different signal pathways. Neuroscience; 156(1): 89-98. 2008;学习记忆的主要研究手段;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;LTP—学习记忆的细胞学基础; 突触可塑性是学习记忆研究方面近年来进展最快、成果最大的研究领域。很多脑区都发现了突触可塑性现象，如小脑、海马、皮层以及伏隔核等。;LTP原理;LTP应用;药物调节的研究，如; Reversal of Aging-Associated Hippocampal Synaptic Plasticity Deficits by Reductants via R