复方清脂颗粒对大鼠的肝毒性实验研究论文.docVIP

　　复方清脂颗粒对大鼠的肝毒性实验研究论文 【摘要】 目的 研究复方清脂颗粒对大鼠肝脏的毒性作用。方法大鼠连续灌胃给予复方清脂颗粒生药52，26和13 g/kg连续8周，同时设对照组。禁食12 h后用水合氯醛麻醉动物，取肝脏称重并计算肝系数，光镜下做病理组织学检查，并测定血清中AST，ALT，ALP和肝组织中SOD和MDA。结果复方清脂颗粒52 g/kg组大鼠的肝重、肝系数、肝组织中MDA量都明显高于对照组.freeleasured, and liver coefficient ination for the liver ed icroscopt.Activities of aspartate amino transferase (AST),alanine aminotransferase (ALT),alkaline phosphatase (ALP) in serum and activity of superoxide dismutase(SOD)and concentration of malondialdehyde(MDA) in liver tissue ined.ResultsLiver controls. Liver coefficient and concentration of MDA increased significantly in rats admi