扶正软坚方对肺纤维化大鼠基质金属蛋白酶及其抑制因子表达的影响论文.docVIP

　　扶正软坚方对肺纤维化大鼠基质金属蛋白酶及其抑制因子表达的影响论文 季旭明，赵启韬，孙敬昌，杨勇，朱庆均，刘恒，郑广娟 【摘要】 目的 研究扶正软坚方对肺纤维化的干预作用及对MMP-9和TIMP-1表达的影响。方法 ethods Sixty male MP-9 al group（P 0.05）. Fuzhengruanjian prescriptions could significantly upgrade the expressions of MMP-9 and degrade the expressions of TIMP-1 in a dose-dependent ycin-induced pulmonary fibrosis in rats, increasing the expression of MMP-9 and suppressing the expression of TIMP-1 should be the mechanisms. 【Key onary fibrosis；matrix metalloproteinase-9；inhibitior of matrix metalloproteinase-1 肺纤维化是多种病因引起的一种慢性炎症性间质性肺疾病，其主要病理改变为弥漫性肺泡炎、肺泡单位结构紊乱和肺纤维化。基质金属蛋白酶-9（MMP-9）、基质金