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Intensive Care Med (2009) 35:371–380 DOI 10.1007/s00134-008-1318-y EXPERIMENTAL Roman Sykora High versus standard-volume haemofiltration Jiri Chvojka Ales Krouzecky in hyperdynamic porcine peritonitis: effects Jaroslav Radej Thomas Karvunidis beyond haemodynamics? Veronika Varnerova Ivan Novak Martin Matejovic Received: 16 April 2008 Abstract Objective: The role of fewer haemofiltration-treated animals Accepted: 15 September 2008 haemofiltration as an adjunctive required noradrenaline support (86, Published online: 14 October 2008 treatment of sepsis remains a con- 43 and 29% animals in the control, The Author(s) 2008. This article is tentious issue. To address the role of HF and HVHF groups, respectively), published with open access at dose and to explore the biological neither of haemofiltration doses S effects of haemofiltration we com- reversed hyperdynamic circulation, Roman Sykora and Jiri Chvojka contributed pared the effects of standard and lung dysfunction and ameliorated equally to this study. high-volume haemofiltration (HVHF) alterations in gut and kidney micro- Electronic supplementary material The in a peritonitis-induced model of vascular perfusion. Both HF and online version of this article (doi: porcine septic shock. Design and HVHF failed to attenuate sepsis- 10.1007/s00134-008-1318-y) contains sup- setting: Randomized, controlled induced alterations in surrogate plementary material, which is available to experimental study. Subjects: markers of cellular energetics, nitro- authorized users.