还原型谷胱甘肽对系统性红斑狼疮患者氧化应激和炎症状态的影响 ....doc

还原型谷胱甘肽对系统性红斑狼疮患者氧化应激和炎症状态的影响 ....doc

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还原型谷胱甘肽对系统性红斑狼疮患者氧化应激和炎症状态的影响 ...

还原型谷胱甘肽对系统性红斑狼疮患者氧化应激和炎症状态的影响( 廖永强1,夏洪娇1,彭可君1,刘剑荣1,胡建康2(337055 萍乡,萍乡市人民医院:检验科1,风湿免疫科2) [摘要] 目的 探索还原型谷胱甘肽对系统性红斑狼疮(systemic lupus erythematosus,SLE)的临床应用价值及最佳治疗方案。方法 2014年1-12我院住院和门诊诊治的中度以上活动性的SLE患者51例。分为口服还原型谷胱甘肽组,常规治疗组,口服+常规治疗组,进行6周治疗。同时设立健康对照组。检测治疗前后SLE患者血清中C-反应蛋白(CRP)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、丙二醛(MDA)、蛋白质羟基,同时采全血检测ESR,并进行分析。结果 无论是口服还原型谷胱甘肽治疗还是常规治疗,均能有效地减少患者血清中CRP,IL-6, TNF-α, MDA,蛋白质羰基和全血血沉水平。而同时采用两种方式一起治疗则效果更佳。结论 使用还原型谷胱甘肽治疗能够有效改善SLE患者的氧化应激和炎症状态,而且与常规治疗的疗效相当,而同时采用两种方式治疗疗效好于单独使用,且治疗期无明显反应。 [关键词]:还原型谷胱甘肽;氧化应激;炎症状态;系统性红斑狼疮 Effect of reduced glutathione on oxidative stress and inflammatory state in patients with systemic lupus erythematosus LIAO Yong-qiang*,XIA Hong-jiao,PENG Ke-jun,LIU-Jian-rong,HU Jian-kang(1Department of Clinical Laboratory, 2Department of Rheumatology and Immunology,Pingxiang,People’s Hospital, Pingxiang 337055,China) [Abstract] Objective To explore the clinical application value and best treatment method of reduced glutathione in patients with systemic lupus erythematosus.Methods Fifty-five SLE patients visited our hospital from January to December 2014,were randomly assigned to receive oral reduced glutathione,using hormones and immunosuppressive therapy or both for 6 weeks.twenty healthy subjects from out-patients clinic for physical examination served as control.The levels of malondialdehyde (MDA),protein hydroxyl,C-reactive protein,interleukin-6(IL-6),tumor necrosis factor(TNF-α) in serum and erythrocyte sedimentation rate (ESR) in whole blood were measured before and after treatment.Results The levels of CRP,IL-6, TNF-α,ESR,MDA, protein hydroxyl were all lower after 6 weeks treatment than those before treatment. the combined therapy of oral reduced glutathione+using hormones and immunosuppressive therapy achieve the best therapeutic effect.Conclusion Either oralling reduced glutathione or using hormones and immunosuppressive therapy,the oxidative stress and inflammatory sate in SLE patients could be improved,but their combinatio

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