动物类中药材质量评价研究概况及分析-中国药事.PDFVIP

中国药事 2017 年 4 月 第 31 卷 第 4 期 381 动物类中药材质量评价研究概况及分析 * 程樱 , 费毅琴 , 肖凌 （湖北省食品药品监督检验研究院，武汉 430075） 摘要 目的：探讨如何进行动物类药材的质量评价，提出从鉴定真伪、质量优劣及安全性等方面综合评 价动物类药材质量的思路。方法：综合分析国内外近十年来动物类药材的鉴定、研究成果，找出研究方 向及技术手段。结果：采用 DNA 分子鉴定技术，解决药材质量真假问题；采用色谱法结合生物测定法， 解决药材质量优劣问题，以及关注外源性安全物质对动物类中药安全性的影响。结论：结合动物药材的 特点，寻找出符合当前动物药材实际应用的品种鉴定与质量检测的方法与指标，是解决动物药材品质评 价问题的关键。 关键词： 动物药材；DNA 分子鉴定；研究概况；质量评价 中图分类号：R917; R95 文献标识码：A 文章编号：1002-7777 2017)04-0381-08 （ doi:10.16153/j.1002-7777.2017.04.006 On Quality Evaluation of Animal Medicinal Materials * Cheng Ying, Fei Yiqin, Xiao Ling (Hubei Institute for Food and Drug Control, Wuhan 430075, China) Abstract Objective: To discuss how to comprehensively evaluate the quality of animal medicinal materials for the aspects of authenticity, quality and safety and provide references for this field. Methods: Identification and research achievements of the animal medicinal materials at home and abroad in the past decade were analyzed to find out research direction and technical means. Results: DNA molecular identification was used to identify the fake medicinal materials. Chromatography combined with bioassay was used to assess quality of the medicinal materials. Attention was also paid to the effect the of exogenous substances on the safety of animal medicine materials. Conclusion: The key to evaluating the quality of animal medicinal materials is to establish appropriate approaches and indicators according to specific identification and quality testing of animal medicinal materials. Keywords: animal medicinal materials; DNA molecular identification; overview; quality evaluation [1] 我国中药资源达12万余种，其中药用动物近 中《中国药典》一