口服米非司酮、肌注甲氨蝶呤以及联合用于治疗未破裂或未流产型异位妊娠效果对比.docVIP

口服米非司酮、肌注甲氨蝶呤以及联合用于治疗未破裂或未流产型异位妊娠效果对比 　　[摘要]目的 探讨口服米非司酮、肌注甲氨蝶呤以及联合用于治疗未破裂或未流产型异位妊娠的疗效。方法 选取2015年1～12月我院妇产科收治的未破裂或未流产型异位妊娠患者120例，按照随机数表法，随机均等分成三组。A组患者应用米非司酮治疗，B组应用甲氨蝶呤治疗，C组应用甲氨蝶呤联合米非司酮治疗。观察三组终止妊娠效果及药物不良反应。结果 C组治愈率为93.3%，B组为75.0%，A组为70.0%，差异有统计学意义（P0.05）。结论 口服米非司酮联合甲氨蝶呤疗治疗未破裂或未流产型异位妊娠疗效优良，治愈率高，优于单用其中一种，值得临床应用 [关键词]异位妊娠；米非司酮；甲氨蝶呤；疗效 [中图分类号] R713.8 [文献标识码] A [文章编号] 1674-4721（2016）12（b）-0120-03 The curative effect comparison of oral mifepristone Intramuscular injection of methotrexate and combination for the treatment of unruptured ectopic pregnancy or abortion YANG Man Department of Obstetrics and Gynecology，Charity Hospital of Shenzhen，Shenzhen 518048，China [Abstract]Objective To explore the curative effect of oral mifepristone intramuscular injection of methotrexate and combination for the treatment of unruptured ectopic pregnancy or abortion.Methods 120 cases of patients with pregnancy from January to December 2015 in our department of obstetrics and gynecology of hospital，were randomly divided into three groups.Patients in group A were treated with mifepristone，group B was treated with methotrexate，and group C was treated with methotrexate combined with mifepristone.The effect of 3 groups of termination of pregnancy and adverse drug reaction were compared.Results The cure rate in group C was 93.3%，group B was 75.0%，the cure rate of group A was 70.0%，the differences were significant （P0.05）.Conclusion Oral mifepristone combined with methotrexate therapy in the treatment of non ruptured or non abortion ectopic pregnancy has good curative effect，high cure rate，better than one，it is worthy of clinical application. [Key words]Ectopic pregnancy；Mifepristone；Methotrexate；Curative effect 近年?恚?异位妊娠的发病率日渐增高，随着检测手段的提高，很多异位妊娠能够提前诊断，及早治疗可提高患者的生活质量[1]。临床中常应用保守用药治疗的方法，一方面减少对患者的创伤，另一方面满足患者对生育的要求。但是，临床中对于异位妊娠患者治疗中的具体用药方案及治疗效果等尚无统一意见。米非司酮为强抗孕激素，能与患者体内孕酮受体结合，亲和力是黄体酮的5倍以上，因此可用于对异位妊娠患者的抗孕治疗。甲氨蝶呤也是一种常用于异位妊娠治疗的药物，通过抑制敏感滋养细胞生长、繁殖，从而使胚胎组织变性坏死，但是，临床中尚缺乏明确应用米非司酮和甲氨蝶呤联合应