化疗对恶性肿瘤患者血糖代谢的影响.pdfVIP

16 海军总医院学报2008年3月第21卷第1期 化疗对恶性肿瘤患者血糖代谢的影响 田 力，杨 平，聂 青，李方明，吴苏冬，郑 伟，朱 奇 (海军总医院放疗科，北京 100037) 摘要：目的 探讨化疗对恶性肿瘤患者血糖代谢的影响。方法 对化疗前血糖水平正常的105例恶性肿 瘤患者，追踪其化疗结束后的血糖检验报告及相关临床资料，并进行回顾性分析。结果 ①化疗后空腹血糖 升高19例，占18．O9 (19／105)。其中明确诊断为糖尿病者 4例，占3．81 (4／105)；糖耐量减低 6例，占 5．71 (6／105)；一过性血糖异常升高9例，占8．57 (9／105)。②化疗诱发的血糖异常多发生在化疗的第 1--3个疗程。③以紫杉醇合并铂类化疗后血糖升高为著(20 )。④不同肿瘤化疗后血糖异常升高发生率无 差异(PO．05)。结论 恶性肿瘤患者接受化学药物治疗后可能会出现血糖异常，甚至发生糖耐量减低或糖 尿病，尤以紫杉醇合并铂类化疗影响为著，应引起重视。 关键词：肿瘤；紫杉醇；血糖；糖尿病 中图分类号：R730．53；R589．1 文献标识码：B 文章编号：1009—3427(2008)01—0016-03 Study on Chemotherapy Induced Disorders of Glucose Metabolism in Patients with Malignant Tumors TIANLi，YANG Ping，NIEQing，LIFang—ming，W【，Su—dong，ZHENG Wei，ZHUQi (Department of Radiation Oncology，Naval General Hospital，Beijing 100037，China) Abstract：Objective To observe the effect of chemotherapy on glucose metabolism in patients with malignant tumors．Methods The blood glucose assay and associated clinical materials of 105 cases with malignant tumors who received chemotherapy from June 2003 to June 2006 were analyzed retrospectively．Results Nineteen cases had elevated fasting blood glucose after chemotherapy．Among them，4 cases were diagnosed as diabetes mellitus，6 cases were diagnosed as impaired glucose tolerance，9 cases were diagnosed as temporarily elevated glucose．This happened most frequently in the 1——3 courses．Conclusion Chemotherapy may induced disorders of glucose metabolism，which happened most frequently in the 1—3 cour— ses，including impaired glucose tolerance or diabetes mellitus． Key words：Malignant tumor；Paclitaxel；Blood glucose；Diabetes mellitus 化疗在恶性肿瘤治疗中起着重要作用，但化疗 例，Ⅳ期47例。其中乳腺癌32例，非小细胞肺癌 药物在体内杀灭癌细胞或抑制癌细胞生长的同时， 46例，鼻咽癌 16例，卵巢癌 5例，食管癌6例。化 对机体正常细胞也有不同程度的损