抗高血压药_课件英文版.ppt

Angiotensin Ⅱ receptor blockers ARB AT1 receptor: vascular smooth muscle, cardiac muscle, brain, kidney and secretion of aldosterone Adrenal zona cells - has regulating effect to the stability of the cardiovascular function. losartan 【 Antihypertensive mechanism 】 Selective blocking AT1 receptor: blocking angiotensin Ⅱ mediated blood vessels Shrinkage, aldosterone release and promote vascular smooth muscle proliferation and effect → Peripheral resistance ↓ Promoting uric acid excretion, inhibiting renal tubule of uric acid absorption, short 【 Clinical application of 】 Each period high blood pressure Step-down features: The oral work fast 2. The role to maintain for a long time: 24 h smooth step-down, 3 ~ 6 weeks for maximum effect 【 side effect 】 relatively less ACEI: Attracted less dry cough and angioneurotic oedema; But still can cause low blood pressure and high potassium. For patients with pregnancy. Promoting uric acid excretion, inhibiting renal tubule of uric acid absorption, short  Pharmacological effects Diastolic small artery smooth muscle, reduce the peripheral vascular resistance, lower blood pressure With heart rate slows, decreased cardiac output Inhibit the secretion of gastrointestinal tract and movement and the protection of gastric mucosa Buck with sedation Reduce intraocular pressure, do not affect the pupil and the adjustment of the lens Pharmacological action and mechanism Activate I1-imidazoline receptor， Make the peripheral sympathetic activity decline, vasodilation, blood pressure drops The excited central postsynaptic membrane receptor alpha 2 Lower levels of plasma renin and aldosterone Inhibit the secretion of gastrointestinal tract and movement and the protection of gastric mucosa Static note clonidine can produce booster for a short period of time (associated with peripheral alpha 2 receptor excited), followed by a long period of time the step-down (central role). Oral with the central role of the dominant, the booster effec