机械通气患者的镇静—培训课件.pptVIP

理想的镇静药物 药理治疗学特性 给药简单方便、无需复杂装置 对塑料或玻璃无吸附 与其他药物无物理性相互作用 水溶性好，无静脉刺激性 价格便宜 Sedation Therapy——Benzodiazepines Sedation Therapy——Diazepam Diazepam can cause prolonged dose-related drowsiness, confusion, and impairment of psychomotor and intellectual functions. Paradoxic excitement can occur. Hypotension, bradycardia, cardiac arrest, respiratory depression, and apnea have been associated with rapid parenteral injection. Allergic reactions have been reported. Irritation at the infusion site and thrombophlebitis may occur. Sedation Therapy——Diazepam Prolonged elimination of diazepam and its metabolite