断裂基因、DNA复制和表达.pptVIP

Reverse transcription Central dogma 中心法则 转录前调控 （二）基因表达的调控 转录水平的调控 转录后调控 翻译水平的调控 翻译后修饰 DNA methylation Histone modification 转录前调控 转录水平的调控 转录后调控 翻译水平的调控 翻译后修饰 蛋白质加工：糖基化 水解 acetylation, methylation, phosphoryation, ubiquitination, sumoylation, ribosylation * Changes in domain structure upon zymogen activation. (a) Domain arrangement of the FXI zymogen, based on the crystal structure of Papagrigoriou et al. (7). The A4 domain (green) mediating dimerization and the three other apple domains are shown in ribbon representation. The two catalytic domains (