耐多药肺结核不良反应分析及其对治疗转归影响.docVIP

耐多药肺结核不良反应分析及其对治疗转归影响，在化疗结束期满后均具有明确治疗转归；其中136例（96.5%）MDR-TB患者完整的接受标准化疗方案。136例MDR-TB患者中有84例（61.8%）发生过不良反应；不良反应发生率最高的是胃肠道反应64例（76.2%），其次为肝毒性30例（35.7%）。其中发生过不良反应的MDR-TB患者化疗成功率为57.1%，未发生过不良反应的MDR-TB患者化疗成功率为88.5%，两者比较差异有统计学意义（χ2=24.482，P=0.000）；未用过药或只用过一线结核化疗药物的MDR-TB患者52例，化疗成功者52例（72.2%）；使用过一线和二线结核化疗药物的MDR-TB患者64例，化疗成功者42例（65.6%）；两者比较差异无统计学意义（χ2=0.842，P=0.445）。结论 标准化疗方案治疗MDR-TB值得临床推广，但患者不良反应发生率较高且对治疗转归存在影响，为在全省内开展MDR-TB的标准化疗提供参考 [关键词] 耐多药肺结核；不良反应；化疗；转归 [中图分类号] R521 [文献标识码] A [文章编号] 1674-0742（2017）03（c）-0019-04 Analysis of Multi-drug Resistant Tuberculosis Adverse Reactions and Effect on the Treatment Outcome SUN Yu-ting First Department of Infectious Disease， Inner Mongolia Autonomous Region Center for Disease Control and Prevention， Hohehot， Inner Mongolia， 010080 China [Abstract] Objective To analyze the occurrence of adverse reactions after adopting the standardized chemotherapy plan in Fourth Hospital of Inner Mongolia and study the effect of adverse reactions on the treatment outcome thus providing reference for the development of MDR-TB standardized chemotherapy in a greater range. Methods 141 cases of MDR-TB patients treated as a group with the standardized pulmonary tuberculosis chemotherapy plan and with obvious outcome in Fourth Hospital of Inner Mongolia from January 2013 to December 2015 were selected as the research objects and the chemotherapy outcome situation of MDR-TB and occurrence of adverse reactions were surveyed. Results The 141 cases of MDR-TB patients had the obvious treatment outcome at the end of chemotherapy， and 136 cases of MDR-TB patients（96.5%）received the standardized chemotherapy plan， and 84 cases of MDR-TB patients had adverse reactions （61.8%）， and the highest incidence rate of adverse reaction was 76.2% （64 cases with gastrointestinal reactions）， the second was hepatotoxicity （30 cases， 35.7%）， and the chemotherapy success rate of MDR-TB patients with adverse reactions was 57.1% and of MDR-TB patients without adverse