因工程微生物的环境监测及生物防御体系研究进展.pdfVIP

生 物 工 程 学 报 Chin J Biotech 2008, March 25; 24(3): 355-362 journals.im.ac.cn Chinese Journal of Biotechnology ISSN 1000-3061 cjb@im.ac.cn © 2008 Institute of Microbiology, CAS CSM, All rights reserved 综 述 1, 2 1 李琴 , 伍一军 1 , , 100101 2 , 100039 : 随着生物技术的发展, 研究人员构建出了大量具有特定功能的基因工程微生物, 这些基因工程微生物在实际 应用时常受到限制, 因为它们释放到环境中有可能带来新的污染。为了减少或消除其对环境的潜在危害, 有必要采取措 施对这些基因工程微生物进行监测和安全控制。通常要求这类基因工程微生物带有便于监测的检测标记以及能进行自 消亡的主动生物防御体系。对基因工程微生物的检测标记以及主动生物防御体系的研究现状进行了综述。 : 基因工程微生物, 环境监测, 主动生物防御体系, 自杀基因 Progress of Environmental Monitoring and Biological Containment System on Genetically Engineered Microorganisms Qin Li1,2, and Yijun Wu1 1 Laboratory of Molecular Toxicology , State Key Laboratory for Integrated Management of Pest Insects and Rodents, Institute of Zoology , Chinese Academy of Sciences , Beijing 100101, China 2 Graduate School of the Chinese Academy of Sciences, Beijing 100039, China Abstract: With the development of biological technology, many genetically engineered microorganisms (GEMs) for special pur- poses have been constructed and developed, but their practical applications in the field are still limited because GEMs may cause new environmental contaminations. To minimize the potential risks, the organisms released to environment need to be monitored and restricted for their distribution. In the laboratory conditions, the GEMs can be wiped off when required using some new biological