他克莫司软膏治疗面部激素依赖性皮炎疗效观察.pdfVIP

大理学院学报 第6眷第12期2007年12月 JOURNAL OF DALI UNIVERSITY VOI．6 No．12 DOC．2007 他克莫司软膏治疗面部激素依赖性皮炎疗效观察 黄 玲，黄 静 (大理学院附属医院皮肤科，云南大理 671000) [摘要]目的：观察外用0．03％445克莫司软膏治疗面部激素依赖性皮炎的临床疗效和安全性。方法：治疗组患 者外用0．03％他克莫司软膏，每日2次，连用4周；对照组给予10％氧化锌软膏外用，每日2次，连用4周，并观察 不良反应。结果：治疗组总有效率为93．55％，对照组总有效率为43．33％，两组疗效比较有显著差异(尸0．O1)。 治疗组不良反应有红宽、灼热感和刺痛感，但可耐受。结论：0．03％他克莫司软膏治疗面部激素依赖性皮炎安 全、有效。 [关键词]他克莫司软膏；激素依赖性皮炎；外用药 [中图分类号]R75l [文献标识码]A [文章编号]1672—2345(2007)12—0021—02 Ciiniai efficacy of facial corticosteroid dependent dermatitis with topical tacrolimus ointment HUANG Ling，HUANG Jing (Department of Dermatology，the Affiliated Hospital of Dali University，Dali，Yunnan 67 1 000，China) 【Abstract J Objective：To investigate the clinical efficacy and safety of topical tacrolimus ointment 0．03％for the beatment of pa— tients with facial steroid corticosteroid dependent dermatitis．Methods：3 1 patients were treated with topical tacrolimus ointment 0．03％ twice a day for 4 weeks．30 patients were treated with topical zinc oxide ointment 1 0％ for 4 weeks in the eontrol group．Mcan— while the adverse events were observed．Resuits：The effective rates are 93、55％ and 43-33％ respectively in the treatment group and the control group．There is a distinct difference between the two groups(P0．05)．The adverse events were e~thema．buring and pricking but it could be bearable．Conclusion：Topical taerolimus ointment 0．03％ is a safe and effective treatment option for the pa— tients with facial corticosteroid dependent dermatitis． 【Key words J tacrolimus ointment；facial cortieosteroid dependent dermatitis；medicine for external use 激素依赖性皮炎是指长期反复外用糖皮质激 岁，平均33．4岁。患者原发疾病常为寻常瘦疮、脂溢 素，停药后原疾病病情加重，并出现特有的体征和 性皮炎、化妆品皮炎