输液袋用聚碳酸酯组合盖中双酚A含量及双酚A向输液中迁.PDFVIP

输液袋用聚碳酸酯组合盖中双酚A 含量及双酚A 向输液中迁移量的测定 王丹丹，金宏(浙江省食品药品检验所，杭州 310004) 摘要：目的 建立输液袋用聚碳酸酯组合盖中双酚A 含量及双酚A 向输液中迁移量的高效液相色谱测定法。方法 采用 Diamosil-C 1 18(4.6 mm×250 mm ，5 μm) 色谱柱；流动相为甲醇-水(80 ∶20) ，检测波长为227 nm ，流速1.0 mL·min 。结果 双 酚A 在 1.354~27.08 ng 内呈良好的线性关系(r=0.999 9) ；聚碳酸酯组合盖中双酚A 含量和双酚A 向输液中迁移量测定的 平均回收率分别为91.7%(RSD=2.3%)和93.9%(RSD=1.8%)。结论 该方法准确、灵敏、简便，适用于对输液袋用聚碳酸 酯组合盖中双酚A 含量及双酚A 向输液中迁移量的测定。 关键词：高效液相色谱法；聚碳酸酯组合盖；双酚A ；迁移 中图分类号：R917.101 文献标志码：B 文章编号：1007-7693(2012)07-0641-03 Determination of Bisphenol A in Infusion Used Combined Cover and Bisphenol A Migration into Infusion by HPLC WANG Dandan, JIN Hong(Zhejiang Institute for Food and Drug Control, Hangzhou 310004, China) ABSTRACT: OBJECTIVE To develop a method for determination of bisphenol A in Infusion Used Combined Cover and bisphenol A migration into infusion by HPLC. METHODS A Diamosil-C 18 column(4.6 mm×250 mm, 5 μm) and a DAD detector was adopted with methanol and water(80 ∶20) as mobile phase . The wavelength was 227 nm, the flow rate was 1. RESULTS The method had a linear range in 1.35427.08 ng (r=0.999 9). The average recovery of bisphenol A 1.0 mL·min and bisphenol A migration was 91.7%(RSD=2.3%) and 93.9%(RSD=1.8%), respectively. CONCLUSION This method is accurate, sensitive, simple, and can be used for determination of bisphenol A and bisphenol A migration into infusion from Infusion Used Combined Cover. KEY WORDS: HPLC; Infusion used combined cover; bisphenol A; migration 聚碳酸酯组合盖中的聚碳酸酯(PC)有无色透 注。有研究证明双酚 A 具有雌激素效应和慢性毒 明、耐用、轻巧和突出的防冲击等特性，因此被 效应，对人特别是孕妇、新生儿和婴儿以及环境 用于输液袋包装，并受到了人们的青睐。聚碳酸 有害，是近几年新认定的“环境内分泌干扰物” 酯生产的化