L-肉碱的生理功能、生物学制备及检测方法研究进展.pdfVIP

※专题论述 lllii1融事 2015, Vol.36, NO.05 205 L-肉碱的生理功能、生物学制备及 检测方法研究进展 杨月英1 ，黄娇芳23 ，顾金杰2 ，史吉平2 ，王红英忡 (1.大连工业大学生物工程学院，辽宁大连 116034; 2. 中国科学院上海高等研究院，生物炼制实验室，上海 201210; 3.上海科技大学物质科学与技术学院，生物灵感工程实验室，上海 201210) 摘要: L- 肉碱即左旋肉碱，又叫维生素BT 是一种广泛存在于动物、植物以及部分微生物体内的活性异构 体，其主要功能是参与脂肪酸的代谢。近年来， L-肉碱越来越广泛地用于新型的功能食品和降血脂新药的开 发，因此，其生产方法和检测都面临更高的技术要求。文章重点综述了L-肉碱的生理功能、生物法制备以及 检测方法，并对其未来发展方向进行展望。 关键词: L- 肉碱:脂肪酸代谢:生物合成法:活性异构体:检测 Advances in Physiologica1 Functions , Biotransformation and Detection of L-Carnitine 2 3 2 2 YANG Yueying\ HUANG Jiaofang • , GU Jinjie , SHI Jiping , WANG Hongying* (1. College of Biologica1 Engineeri晤， Da1ian Polytechnic Univers町， Da1ian 11ω34， China; 2. Laboratory of Biorefinery, Shanghai Advanc巳dRese缸由Institute， Chinese Academy of Sciences, Shanghai 201210, China; 3. Integrative Bio也spired Molecular Engineering Laboraω巧， Sch∞，1 of Physica1 Science and Technology , ShanghaiTech University , Shanghai 201210, China) Abstract: L-Carnitine , a1 so named vitamin BT is an active compound found in anima1s and vegeta1 tissues , as well as in micr，∞rg扭isms. L-carnitine plays an important role in fatty acid metabolism. In recent ye缸s， L-carnitine has been increasingly used as a novel fi创xl additive and clinically applied in reducing blαxl f;况， so that 也e demand for L-car凰山e is increasing in the worldwide market, and the development of manufacturing and de阳tion methods is needed. Herein, the physiol鸣ica1缸nctions， biotr缸lSformation 姐d detection methods of L-carnitine are summarized, and the future dir民tions of L-carnitine are pu