红景天对兔烫伤后多器官功能障碍综合征的治疗作用论文.docVIP

　　红景天对兔烫伤后多器官功能障碍综合征的治疗作用论文 .freelultiple organ failure;rhodiola;nitric ox-ide;rabbits Abstract:AIM To study multiple organ dysfunction syn-drome（MODS）of the rabbit after burn and the therapeutic effect of Rhodiola and to analysis its acting mechanism.METHODS The rabbit MODS model at early stage after burn burn group，burn group，Rhodiola oral adminstra-tion group，burn and Rhodiola therapy group.Mean arterial pressure（MAP），central venous pressure（CVP），cardiac output（CO）onitored，and systemic vascular resis-tance（SVR）and cardiac index（CI）onary alveolar perfusion protein（PAPP）and plasma total protein（TP）ined，and the index of pulmonary permeability PAPP/TP%.Partial pres-sure of oxygen of arterial blood（PaO2 ），oxygen saturation of arterial blood（SaO2 ）easured.The levels of serum creatine phosphokinase（CK），glutamic pyruvic transaminase（GPT），urea（BU），creatinine（Cr）and blood platelet count（PLT）.NO3- and NO2- contents，the metabolic products of nitric oxide in blood and pulmonary alveolar perfusion easured by Griess method.RESULTS Rabbits developed MODS48h after burn.The dysfunctions of the heart，the liver and kidney onary alveolar perfusion.Functions of the heart and kid-neys markedly improved，NO contents in the blood and pul-monary alveolar perfusion markedly rose in the burn and Rhodiola therapy group.CONCLUSION Rhodiola had pro-tective effect on the functions of the heart，kidneys and lungs of burned animals，the increases in NO synthesis and the blood perfusion of organs might be one of the mechanisms to prevent the development of MODS. 0 引言 严重烧伤后延迟复苏、感染等因素可能造成多器官功能障碍（MODS）或多器官功能衰竭（MOF）发生，MOF的病死率高达70%～100%［1］ ，国内外学者对其发病机制、防治措施均进行过广泛探讨.红景天（Rhodiola）具有抗缺氧、抗疲劳、抗微波辐射功能，可提高机体对高原的适应能力等［2］ .其有效成分为红景天甙（Salidroside），在我国西北、西南高原缺氧地区已被用于防治高原适应不全症.国外发现红景天提取物可抑制DNA杂乱合成，提高细胞内DNA修复的效率从而能抗基因突变［3］ .赵贺玲等［4，5］ 的研究表明，红景天可抑制常氧及缺氧状态下离体培养的兔肺动脉平滑肌细胞增殖、DNA合成及c-fos，c-myc原癌基因表达.我们旨在观察兔烫伤后早期MODS的发生以及红景天的防治作用，并初步探讨其防治作用的机制. 1 材料和方法 1.1 材料 雄性大耳白兔28只，体质量（2.4±0.2）kg，由第四军医大学实验动物中心提供.