氟比洛芬酯注射液联合芬太尼静脉输注用于术后镇痛临床观察.docVIP

氟比洛芬酯注射液联合芬太尼静脉输注用于术后镇痛临床观察[摘要] 目的：观察氟比洛芬酯注射液联合芬太尼静脉输注用于术后镇痛的效果。方法：将100例ASA Ⅰ～Ⅱ级患者随机分成两组，A组（对照组）术后持续静脉输注芬太尼15 μg/h；B组（实验组）术前15 min静脉推注氟比洛芬酯注射液1 mg/kg，术后持续静脉输注芬太尼15 μg/h。观察并记录患者术后1、3、6、12、18、24 h视觉模糊（VAS）评分，镇痛满意度，追加补救镇痛药的例数及不良反应的发生例数。结果：术后1、3、6、12 h B组镇痛VAS评分低于A组（P＜0.01或P＜0.05），18 h后两组镇痛评分差异无统计学意义。A组优良率为64%，B组为96%，两组镇痛优良率比较差异有统计学意义（P＜0.05），在术后1～12 h内A组有18例需肌注哌替啶来缓解疼痛，B组仅2例，两组比较差异有统计学意义（P＜0.05）。结论：术前15 min静脉输注氟比洛芬酯注射液1 mg/kg增强了小剂量芬太尼的镇痛效果，同时减少了阿片类药物的用量，降低了不良反应发生率 [关键词] 氟比洛芬酯；芬太尼；术后镇痛 [中图分类号] R969.4 [文献标识码] A [文章编号] 1673-7210（2011）12（a）-082-03 Clinical observation of Flurbiprofen Axetil Injection combined with intravenous Fentanyl in the postoperative analgesia DUAN Zongwei, HUANG Hailing, DAI Jingwei Department of Anesthesiology, the First Affiliated Hospital of Xiamen University, Xinglin Branch, Fujian Province, Xiamen 361022, China [Abstract] Objective: To observe the effect of Flurbiprofen Axetil Injection combined with intravenous Fentanyl in the postoperative analgesia. Methods: 100 patients in ASA Ⅰ-Ⅱ level were randomly divided into two groups, the control group (group A) was given persistent intravenous Fentanyl, 15 μg/h; the experimental group (group B) was given intravenous Flurbiprofen Axetil Injection of 1 mg/kg at 15 minutes before the operation and persistent intravenous Fentanyl 15 μg/h after the operation. The postoperative 1, 3, 6, 12, 18 and 24 h visual analogue scale (VAS) scores and analgesic satisfaction, the number of additional remedy analgesics and adverse reaction were observed and recorded. Results: The VAS analgesia score of group B at 1, 3, 6 and 12 h after operation were lower than group A (P＜0.01 or P＜0.05). At 18 h, the difference of the analgesia score between the two groups was not significant. The good rate of group A was 64%, which of group B was 96%, there was significant difference of analgesia good rate between the two groups (P＜0.05). During 1-12 h after operation, there were 18 patients in group A and 2 cases in