蝉蜕对哮喘大鼠模型支气管和肺组织形态学及血清中TXB2和6-keto—PGF1α的影响.pdfVIP

中药药理与临床2007；23(6) 45 l8 韩燕．中药黄芪的研究概况．河南中医学院学报，2003；18(6)： 86～88 Effect of extract of Astragalus on fatique and recovecry protocol of mice Wu Yun，Wu Dazhen，Hu Zhibi (Institute of Chinese Materia Medica，Shanghm University of Chinese Medicine，Shanghai 201203) Objective：to observe the effect of extract of Astragalus(EA)given by intragastrie administration and incubation in vitro on fatigue and recovery protocol of mice．Methods：1)EA was given by intragastrie administration for 7 days，extensor digitorum longus(EDL)and soleus muscles were excised quickly，then fatigued by low—frequency electrical stimulation，the tensions of the fatigue and recovery were deter- mined．2)The normal EDL and soleus muscles were excised and incubated by EA for 30 min，theft fatigued by low—frequency electrical stimulation，the rates of the fatigue and recovery were determined．Results：EA had no effect on the fatigue development but could accelerate recovery from muscle fatigue．For soleus muscles，the recovery rate was not affected by EA．For EDL muscles，the recovery rate WaS signiti- cant accelerated．Conclusion：EA could accelerate recovery of EDL muscles from fatigue． Key words Astragalus；soleus；extensor digitorum longus；fatigue；tension 蝉蜕对哮喘大鼠模型支气管和肺组织形态学及血清中TXB：和6-keto—PGFl ot的影响 王永梅 ，徐树楠 ，张美玉 ，候仙明 ( 河北医科大学中医学院，石家庄 050091； 成都中医药大学，成都 610075) 摘 要 目的：探讨蝉蜕治疗支气管哮喘的作用机制。方法：以不同浓度蝉蜕提取物喷雾作用于哮喘模型大鼠，观察其对大 鼠支气管和肺组织形态学及血清中TXB 和6-keto—PGF． 的影响。结果：支气管、肺组织炎症细胞浸润明显减少，管腔内渗出物减 少，基底膜增生减轻，细支气管黏膜上皮完整，无明显细胞水肿，充血；血清中TXB 水平降低，而6-Keto-PGF． 水平上调，TXB ／6一Ke— to—PGF 比值显著性下降。结论：蝉蜕治疗支气管哮喘的机制在于缓解慢性炎症、改变”微观血瘀”状态，进而缓解支气管平滑肌的 痉挛。 关键词 蝉蜕；哮喘；TXB2；6-keto—PGF 蝉蜕对支气管哮喘具有较好的治疗效果。本课题组前期 司产品，OVA批号为A一5253；灭活百日咳杆菌疫苗，北京生物制 药理实验已证实蝉蜕确具有镇咳、祛痰、平喘作用…；其平喘作