Bcl-2 Bax 福建医科大学(英文版).pdfVIP

Arch Toxicol DOI 10.1007/s00204-011-0745-7 MOLECULAR TOXICOLOGY 2,5-Hexanedione induces human ovarian granulosa cell apoptosis through BCL-2, BAX, and CASPASE-3 signaling pathways Yan Sun · Yuan Lin · Hong Li · Jin Liu · Xiaohua Sheng · Wenchang Zhang Received: 30 June 2011 / Accepted: 11 August 2011 © Springer-Verlag 2011 Abstract Studies have shown that 2,5-hexanedione (2,5- decreased. However, a marked dose-dependent increase in HD) is the main active metabolite of n-hexane in the human the expression of BAX and active CASPASE-3 (p17) was bod