survivin（IHC） 安徽医科大学(英文版).pdfVIP

Med Oncol DOI 10.1007/s12032-011-0053-3 ORIGINAL PAPER CIP2A with survivin protein expressions in human non-small-cell lung cancer correlates with prognosis Peng Xu • Xiao-Lan Xu • Qiang Huang • Zhi-Hong Zhang • Yan-Bei Zhang Received: 22 July 2011 / Accepted: 19 August 2011 Springer Science+Business Media, LLC 2011 Abstract Cancerous inhibitor of protein phosphatase 2A Keywords CIP2A Survivin Immunohistochemical (CIP2A) and survivin are aberrantly expressed in a wide staining Prognosis range of human cancers, including lung tumors. In order to assess the expressions of these two proteins in Chinese Abbreviations non-small-cell lung cancer (NSCLC) patients and deter- NSCLC Human non-small-cell lung cancer mine their correlation with prognosis, NSCLC tissues and CIP2A Cancerous inhibitor of protein phosphatase 2A adjacent non-cancerous normal lung tissues were collected DAB Diaminobenzidine from 97 patients undergoing surgical treatment and eval- PBS Phosphate-buffered saline uated by immunohistochemistry staining. CIP2A or survi- HR Hazard ratio vin immunoreactivity was detected in significantly more CL Confidence interval NSCLC tissues than in adjacent non-cancerous lung tissues (P \0.05). Moreover, CIP2A expression in NSCLC correlated with TNM stage, while survivin expression correlated with TNM stage and lymph node metastasis. Kaplan–Meier survival analysis showed that the overall Introduction survival times in patients expressing either CIP2A or sur- vivin protein in NSCLC were shorter. COX regression Lung cancer is the leading cause of death worldwide, and analysis indicated that expression of CIP2A protein was an the non-small-cell