多发性骨髓瘤骨病发病机制及细胞因子靶向治疗.pdf

医学综述 2007 年 10 月第 13 卷第 20 期 　Medical Recapitulate ,October 2007 ,Vol . 13 ,No . 20 ·1553 · 不应答 ,Pokemon 在多种人类肿瘤中过表达 。由于 Pokemon 在 Pokemon in cellular transformation and ARF repression [J ] . Nature , ( ) 肿瘤细胞转化过程中发挥关键作用并与肿瘤发生密切相关 , 2005 ,433 7023 :278285 . [8 ] 　Lee DK ,Suh D , Edenberg HJ , et al . POZ domain transcription factor , 因此 ,有望成为肿瘤治疗的新靶点 。 FBI1 , represses transcription of ADH5FDH by interacting with the 参考文献 : zinc finger and interfering with DNA binding activity of Sp 1[J ] .J Biol Chem ,2002 ,277 (30) :2676126768. [ 1] 　Pessler F ,Pendergrast PS ,Hernandez N . Purification and characteriza [9 ] 　Liu CJ ,Prazak L ,Faj ardo M , Yu S , et al . Leukemialymphomarelated tion of FBI1 ,a cellular factor that binds to the human immunodeficien factor ,a POZ domaincontaining transcriptional repressor ,interacts with cy virus type 1 inducer of short transcripts[J ] . Mol Cell Biol ,1997 ,17 histone deacetylase1 and inhibits cartilage oligomeric matrix protein (7)