不同类型格林_巴利综合征患者单个核细胞免疫学致病特征的实验研究_吴梅.pdfVIP

1998 8 36 8 ·453 · ·· - 吴梅　蔡方成 【】　　(AIDP)(AMAN) -(GBS)(PBMC)。　 11 AIDP 14 AMAN PBMC , 132 25 。 　AMAN PBMC , 23.4%, (0.2%);AIDP PBMC , (22.8%), (5.2%)。。, 。 (IL)-2、IL-6、-α IgG 。PHA AIDP PBMC , LPS AMAN PBMC , -α。　GBS PBMC , , 。 。 【】　IGG　　　　, Experimental neuropathies inducedby thePBMCsofGuillain-Barrésyndromeindifferent clinicalpatterns Wu Mei , Cai Fangcheng .Children ′s Hosp ital, Chongqing University of Medical Sciences , Chongqing 400014 【Abstract 】　Objective　To explore the pathoge etic role of peripheral blood mo o uclear cells (PBMCs) take from Guillai -Barré sy drome (GBS )patie ts with acute i flammatory demyeli ati g poly europathy Methods　Super ata ts of PBMCs from 11 AIDP a d (AIDP)a d acute motor axo al europathy (AMAN). 14 AMAN patie ts were i jected peri eurally at 132 lateral sciatic erves of Wistar rats a d i trave ously i 25 rats.Results　Axo al dege eratio w as the mai pathological patter alo g the rat erve i AMAN super- ata t group (23.4%)with a few demyeli ati g fibers (0.2%).I co trast, 5.2%fibers were u dergoi g demyeli atio i AIDP group eve though there were also sig ifica t axo al dege eratio (22.8%).The i ci- de ce of axo dege erati g a d demyeli ati g fibers were e ha ced more tha two times after the peri eural i jectio with PBMC super ata ts added with compleme t tha that without compleme t.No ab ormality could be detected o the sectio s of liver, kid ey a d brai tissues i 8 rats with experime tal europathy i - duced already by i trave ous PBMC super ata t.There were striki g high level of IL-2, IL-6, TNF-αa d IgG i the super ata t of PBMCs from both groups.Sig ifica t i crease of demyeli ati g fibers w as co sis- te tly caused by PBMC super ata t of AIDP after stimulatio with p