氧气驱动雾化吸入用复方异丙托溴铵溶液防治支气管哮喘急性发作临床观察.doc

氧气驱动雾化吸入用复方异丙托溴铵溶液防治支气管哮喘急性发作临床观察 　　【摘要】 目的 探?氧气驱动雾化吸入用复方异丙托溴铵溶液治疗支气管哮喘急性发作期的临床治疗效果。方法 50例支气管哮喘急性发作期患者， 随机分为治疗组（26例）和对照组（24例）。对照组患者采用解痉、平喘、抗炎等对症治疗， 治疗组患者在对照组基础上给予氧气驱动雾化吸入用复方异丙托溴铵溶液治疗， 比较两组患者治疗前及治疗3 d后桡动脉血中血氧分压（PaO2）、二氧化碳分压（PaCO2）指标以及静脉血中白三烯B4（LTB4）的含量。结果 治疗组总有效率为96%， 明显高于对照组的67%， 差异有统计学意义（P0.05）。结论 氧气驱动雾化吸入用复方异丙托溴铵溶液用于支气管哮喘急性发作期的治疗， 不仅显著缓解了患者的症状， 而且提高了患者的康复、生存质量， 值得广大临床医生借鉴、应用、推广 【关键词】 支气管哮喘；吸入用复方异丙托溴铵溶液；氧气驱动；雾化；血氧分压；二氧化碳分压；白三烯B4 DOI：10.14163/j.cnki.11-5547/r.2017.09.050 Clinical observation on oxygen-driven atomizing inhalation of compound ipratropium bromide solution in prevention of bronchial asthma acute attack SONG Wei-rong， ZHAO Hua. Shenyang Medical College Affiliated Second Hospital， Shenyang 110002， China 【Abstract】 Objective To explore the clinical treatment effect of oxygen-driven atomizing inhalation of compound ipratropium bromide solution in prevention of bronchial asthma acute attack. Methods A total of 50 bronchial asthma of acute attack stage patients were randomly divided into treatment group （26 cases） and control group （24 cases）. The control group received symptomatic treatment of spasmolysis， relieving asthma and anti-inflammatory， and the treatment group received oxygen-driven atomizing inhalation of compound ipratropium bromide solution for treatment on the basis of the control group. Comparison were made on radial artery blood of partial pressure of blood oxygen （PaO2）， partial pressure of carbon dioxide （PaCO2） index and venous blood of leukotriene B4 （LTB4） content before treatment and after 3 d of treatment in two groups. Results The treatment group had obviously higher total effective rate as 96% than 67% in the control group， and the difference had statistical significance （P0.05）. Conclusion For the treatment of bronchial asthma acute attack， oxygen-driven atomizing inhalation of compound ipratropium bromide solution can not only significantly relieve symptoms of patients， but also improve recovery and survival quality of pa