生长抑素联合特利加压素治疗肝硬化急性食管胃底静脉曲张破裂出血患者临床疗效.docVIP

生长抑素联合特利加压素治疗肝硬化急性食管胃底静脉曲张破裂出血患者临床疗效 　　【摘要】 目的 探?生长抑素联合特利加压素作用于肝硬化急性食管胃底静脉曲张破裂出血的临床效果。方法 50例肝硬化急性食管胃底静脉曲张破裂出血患者， 随机分为观察组（26例）和对照组（24例）。对照组给予生长抑素治疗， 观察组给予生长抑素联合特利加压素治疗。比较两组临床效果。结果 观察组止血时间为（6.1±2.4）h， 短于对照组的（8.3±2.8）h， 差异有统计学意义（t=2.9900， P=0.00440.05）， 两组患者未经处理不良反应均自动消失， 未对治疗产生负面影响。结论 在肝硬化急性食管胃底静脉曲张破裂出血的治疗中， 采用生长抑素联合特利加压素治疗整体效果良好， 值得在临床实践中予以借鉴并推广 【关键词】 肝硬化；急性食管胃底静脉曲张破裂出血；生长抑素；特利加压素 DOI：10.14163/j.cnki.11-5547/r.2016.33.050 Clinical effect by somatostatin combined with terlipressin in the treatment of liver cirrhosis acute esophagogastric variceal bleeding HU Feng-yan. Department of Internal Medicine， Liaoning Beizhen City Second Peoples Hospital， Beizhen 121308， China 【Abstract】 Objective To investigate clinical effect by somatostatin combined with terlipressin in the treatment of liver cirrhosis acute esophagogastric variceal bleeding. Methods A total of 50 patients with liver cirrhosis acute esophagogastric variceal bleeding were randomly divided into observation group （26 cases） and control group （24 cases）. The control group received somatostatin for treatment， and the observation group received somatostatin combined with terlipressin for treatment. Clinical effects were compared between the two groups. Results The observation group had shorter hemostasis time as （6.1±2.4） h than （8.3±2.8） h in the control group， and the difference had statistical significance （t=2.9900， P=0.00440.05）. Adverse reactions in both groups were relieved without special treatment， and they showed no negative influence on treatment. Conclusion Implement of somatostatin combined with terlipressin shows excellent effect in the treatment of liver cirrhosis acute esophagogastric variceal bleeding， and this method is worth clinical application， reference and promotion. 　　【Key words】 Liver cirrhosis； Acute esophagogastric variceal bleeding； Somatostatin； Terlipressin 从临床实践来看， 急性食管胃底静脉曲张破裂出血是临床上相对较为常见的一类危急病症， 也是导致肝硬化失代偿期患者死亡的主要原因[1， 2]。随着临床研究的深入， 发现生长抑素联合特利加压素能够强化止血， 取得满意的治疗效果。本