2015科技论文的阅读与写作4概要1.ppt

科技论文的阅读与写作 第五讲 Summary Chromatin is important for the regulation of transcription and other functions, yet the diversity of chromatin composition and the distribution along chromosomes are still poorly characterized. By integrative analysis of genome-wide binding maps of 53 broadly selected chromatin components in Drosophila cells, we show that the genome is segmented into five principal chromatin types that are defined by unique yet overlapping combinations of proteins and form domains that can extend over 100 kb. We identify a repressive chromatin type that covers about half of the genome and lacks classic heterochromatin markers. Furthermore, transcriptionally active euchromatin consists of two types that differ in molecular organization and H3K36 methylation and regulate distinct classes of genes. Finally, we provide evidence that the different chromatin types help to target DNA-binding factors to specific genomic regions. These results provide a global view of chromatin diversity and domain organization in a metazoan cell. Graphical Abstract Author instructions A Graphical Abstract should allow readers to quickly gain an understanding of the main take-home message of the paper and is intended to encourage browsing, promote interdisciplinary scholarship, and help readers identify more quickly which papers are most relevant to their research interests. Authors must provide an image that clearly represents the work described in the paper. A key figure from the original paper, summarising the content can also be submitted as a graphical abstract. Graphical Abstracts should be submitted as a separate file ?Biodegradable star HPMA polymer–drug conjugates: Biodegradability, distribution and anti-tumor efficacy, Tomá? Etrych, Lubomír Ková?, et al., Journal of Controlled Release, Volume 154, Issue 3, 25 September 2011, Pages 241-248 Targeting the lymphatics using dendritic polymers (dendrimers), Lisa M. Kaminskasa, Christopher J.H. Porter, Advanced D