42 抗结核病药及抗麻风病药(国外英文资料).docVIP

42 抗结核病药及抗麻风病药 The forty-fourth chapter, anti tuberculosis drugs and anti leprosy drugs There are many kinds of anti TB drugs, the clinical efficacy, less adverse reaction, low cost and convenient use of the drug known as first-line anti tuberculosis drugs, according to the domestic situation, to isoniazid, streptomycin and para aminosalicylic acid sodium as first-line anti tuberculosis drugs, many countries have B ETHAMBUTOLE replaced streptomycin and convenient to aminosalicylic acid sodium in the first-line anti tuberculosis drugs. 44.1 isoniazid (isoniazid, rimifon, INH) The utility model has the advantages of stable property, easy dissolving in water, high efficiency, low toxicity, low price and convenient application. pharmacological action Have highly selective effect on Mycobacterium tuberculosis of other bacteria, no effect, strong antibacterial activity, has bactericidal effects on growth and reproduction in the period of Mycobacterium tuberculosis, and to improve the concentration of stationary phase bacteria killing effect. Penetration is good, can penetrate into macrophages, but also penetrate the fiber cavity and dry sample lesions, the activity is 500 times stronger than streptomycin. Isoniazid single resistance bacteria, such as a separate application for 3 months, about 70% cases of sputum isolated drug-resistant strains, such as streptomycin, rifampicin and containing, can greatly retard drug resistance and enhance the curative effect. The mechanism of antimicrobial action has not yet been fully elucidated. It may interfere with the metabolism of bacteria, proteins, folic acid, sugar, fat, and inhibit the synthesis of mycobacterial acids, which can lead to bacterial death. In vivo process Oral absorption of fast and complete, after 1 to 2 hours to reach the peak of blood drug concentration, is widely distributed in various tissues and body fluids, meningeal inflammation, concentration in cerebrospinal fluid with the same blood concentration almost