量子点在细胞以及体内生物中成像的研究进展.pdfVIP

材料导报A. 综述篇 • 16 • 2012 年 1 月(上)第 26 卷第 1 期 量子点在细胞以及体内生物中成像的研究进展祷 邱月琴，蔡继业 (暨南大学生物纳米技术实验室，广州 510632) 摘要 量子点是一种荧光半导体纳米材料，与生物分子结合成一种高亮度而稳定的荧光探针应用于生物成 像。通过生物成像可观察量子点标记分子与其靶标的相互作用，实时观ijJ1j其在活细胞及活体中的运行轨迹，实现对 细胞水乎及在活体层次的研究。利用这种生物成像技术还可以研究疾病的发生发展过程。介绍了量子点的光学特 性，重点综述了量子点在细胞、体内生物成像中的应用，并展望了其发展前景。 关键词 量子点荧光探针 生物成像临床诊断 Development of Quantum Dots for Cellular and in Vivo Animals Imaging QIU Yueqin , CAI Jiye Biological Nanotechnology Laboratory , Jinan University , Guangzhou 510632) Abstract Lurninescent quanturn dots (QDs)咽rniconductor nanocrystals are a prornising alternative to organic dyes for fluorescence-based applications. They have unique optical and electronic properties , with sÎze- tunable light ernission , superior signal brightness , resistance to photobleaching , and broad absorption spectra for sirnultaneous ex- citation of rnultiple fluorescence colors. Also Q Ds pro白de a versatile nanoscale scaffold for designing rnultifunctional nanoparticles with both irnaging and therapeutic functio n. When linked with targeting ligands such as antibodies , pe- ptides or srnall rnolecules , Q Ds can be used to target cells biornarkers as well as turnor vasculatures with high affinity and specificity. Researchers have developed procedures for using QDs cellular and in vivo anirnals irnaging so far , de- rnonstrated their use for long-term rnulticolor irnaging of live cells and in vivo. The photo-characters are introduced and the irnplications of quant四n dots in biological irnaging are illustrated , and the future of quanturn dots is 1∞kah创d. Key WOl由 quant山n dots ,