ABCC1介导多药耐药机制及其逆转的研究进展.pdfVIP

# 430# 20 4 V o l. 20 N o. 4 2007 4 Journa l of M edical Postgradu ates A pr. 2007 # # ABCC1介导多药耐药机制及其逆转的研究进展 李雅婷, 窦 骏 ( , 210009) , ATP ( A BC ) ABCC 1 ABC, , A BCC 1 ABCC1; ; ; * R 962 A 1008-8 199( 2007) 04-04 30-04 Advance inmechanism studyofmulti-drug resistancemediatedbyABCC1 and itsreverse L I Y a-t ing review ing, DOU Jun checking (Department of PathogenicBiology and Immunology, School of BasicM edicalScience, Southeast Universi- ty, anj ing 210009, Jiangsu, China) Abstract: M ult-i drug resistance( MDR) is the m ost frequ ent reason for tum or chem otherapeut ic fa ilure. AT P b inding cassette( ABC) drug transporters play an mi portant ro le in tum or MDR. ABCC 1 is one o f the m em bers of ABC tran sporter super-fam ily , wh ich lead to drug risistance v ia d iscarding drug out o f cell or chang ing the drug d istribution in a cel.l In th is art ic le, w e review ed the advance in MDR m ed iated by ABCC 1 and its reverse. Keywords: A BCC 1; M u lt-i drug resistance; T um or chem otherapy; R everse cassette, A BC) , ABC 0 , ABC [ 1] 48 , 7 , ( A ~ G ) , MDR , 9 , BCG , , ABCB 1 ( P-gp /MDR 1) A BCB4 ( MDR 3 ) A BCB 11 ( mu lt-i drug