Aβ42 gene vaccination reduces brain amyloid plaque burden in transgenic mice.pdfVIP

NIH Public Access Author Manuscript J Neurol Sci . Author manuscript; available in PMC 2006 August 4. N Published in final edited form as: I H J Neurol Sci . 2006 May 15; 244(1-2): 151–158. - P A A Aβ gene vaccination reduces brain amyloid plaque burden in 42 u t h transgenic mice o r M a a b c d Baoxi Qu , Philip J. Boyer , Stephen Albert Johnston , Linda S. Hynan , and Roger N. n a,* u Rosenberg s c aAlzheimer’s Diseases Center, Department of Neurology, University of Texas Southwestern r i p Medical Center, 5323, Harry Hines, Dallas, 75390-9036, United States t bDepartment of Pathology, University of Texas Southwestern Medical Center, United States cCenter for Innovations in Medicine/Biodesign Institute, The Arizona State University, United States dCenter for Biostatistics and Clinical Science and Department of Psychiatry, University of Texas Southwestern Medical Center, United States N I Abstract H - P Objective: To demonstrate that in APPswe/PS1DE9 transgenic mice, gene gun mediated Aβ gene 42 A vaccination elicits a high titer of anti-Aβ antibodies causal of a significant reduction of Aβ 42 42 A deposition in brain. u t h o Methods : Gene gun immunization is conducted with transgeni