血管外皮细胞瘤临床病理分析.pdfVIP

· 32· 医药论坛杂志 2007年12月 第28卷 第23期 血管外皮细胞瘤临床病理分析 吕祥瑞，靳双周 焦作市人民医院病理科 焦作市 454000 摘要 目的 探讨血管外皮细胞瘤的临床病理特点、诊断、鉴别诊断依据。方法 回顾21例血管外皮瘤 的临床病理资料，采用HE、免疫组织化学技术进行观察分析，并对14例进行了随访。结果 血管外皮细胞瘤成 年人多见，男女比例无明显差别。组织学上为低度恶性肿瘤，但是部分恶性程度较高。本组低度恶性血管外皮 瘤(15例)、高度恶性血管外皮瘤(6例)。随访14例，随访时间平均4年，其中6例死亡或转移。免疫组化示： Vimentin(++)、Factor~a(一)、HLA—DR(一)、CD34(一)、SMA(一)、desmin(一)、myosin(一)。结论 血管外 皮瘤是从血管外皮细胞发生的恶性肿瘤。其生物学行为大都表现为恶性，极少数也有良性经过。组织形态、免 疫组织化学和病史相结合有助于该病的正确诊断。 关键词 血管外皮瘤；软组织肿瘤；病理；诊断 中图分类号：R732．2 文献标识码：B 文章编号：l672．3422(2007)23-0032-03 Clinicopathologic Analysis of Hemangiopericytoma LU Xiangrui Department ofpathology,Jiaozuo Peoples Hospital，Jiaozuo 454000，China ABSTRACT Objective To study the clinic0path0l0gic features，histologic diagnosis and dif- ferential diagnosis of hemangi0pe cytoma．Methods Clinical and pathology data of 21 hemangioperi— cytoma were analyzed retrospectively by HE and Vimintin FactorVIIIa HLA—DR CD34 desmin myo— sin markers by immun0hist0chemistry．The 1 4 cases had been investigated after treatment．Results Hemangiopencytoma mainly occurred in adult people．The ratio of male to female was no differentia1． Follow—up data were available in 14 patients and 6 of them had local recurrences or had been dead． Immuno——histochemiscal study showed that the positive reactions for Vimentin were revealed in all of the cases．That is，vimentin(++)，FactorⅧa(一)，HLA—DR(一)，CD34(一)，SMA(一)，desmin (～)，Myosin(一)。Conclusion Hemangi0pe cyt0ma is a soft tissue malignant tumor with pericytes differentiation．The Biology behaviours of hemangi0pericyt0ma could be low or hi gh malignant．There are no obvious ambit between them in histology．Correct diagnosis relys on detailed pathologic assess— ment、application