氯离子通道ClC_3研究进展_陈临溪要领.pdfVIP

中国药理学通报 Chinese Pharmacological Bulletin 2002 Oct; 18(5) # 481 # r r 氯离子通道ClC-3 研究进展* ( 中山大学中山医学院药理学教研室, 广州 510080) R 3291 25 [ 2] ClC-3 A 1001-1978(2002)05-0481-06 [3] [ 4] , ClC ClC-3 , ,ClC-3 13 , N C ClC-3, , (Fig 1,Duan, 1997), ClC-3 - 0 mV, I - 760 , Cl , DIDStamoxifen ATP ClC-3ClC-39115% ,PKC , , 9814% ;ClC-3; ; ClC-3 [ 5] 85 ku , 65 70 ku ClC-3 - (Cl ) , , ClC-3 - [ 6] , Cl ClC-3 80 ku - T84 hClC-3 90~ Cl , [7] ,/ 0, 120 ku ClC-3 NIH/3T3 , ,, gp ClC-3 cDNA - , 579 Cl ( chloride channel) , 1990 Jentsch (N579K ClC-3) ,, - - - - - Cl (voltage-gated chloride channel), I Cl Cl I , [1] - Cl , ClC-3579 - Cl (ClC), ClC 9 ClC , ClC-3NIH/ 3T3 ClC-3 51 ClC 1~ 17, ClCKa, ClCKb, ABC3 , , PDBu C( protein - kinase C, PKC) I , Cl 30%~ 80% ClC-3 , 362 PKC ,