外周血NLR、PLR两种比值与乳腺癌分子分型的相关性研究.pdfVIP

目 录 中文摘要·····································································1 英文摘要············································································3 研究论文 外周血NLR 、PLR 两种比值与乳腺癌分子分型的相关性研究 前言·····································································5 材料与方法··································································7 结果······························································13 附图························································2 2 附表······························································26 讨论······························································4 9 结论·············································································54 参考文献·······························································55 综述 肿瘤炎性微环境与乳腺癌·········································59 致谢···············································································69 个人简历··········································································70 万方数据 中 文 摘 要 外周血NLR 、PLR 两种比值与乳腺癌分子分型的相关性研究 摘 要 目的：探讨外周血 NLR （中性粒细胞与淋巴细胞绝对值的比值）、 PLR （血小板与淋巴细胞绝对值的比值）两种比值与乳腺癌各亚型的相关 性，评价NLR 、PLR 两种比值与乳腺癌各亚型预后的关系，为临床提供 可借鉴的治疗方法及理论依据。 方法：采用回顾性分析其临床资料的方法，从河北医科大学第四医院 2008 年2 月至2009 年9 月收治的所有乳腺癌患者中，按照入选标准和排 除标准共选取303 例纳入本次研究。所有患者均于入院次日清晨6 时静息 状态下抽取空腹静脉血，检测血常规。所选乳腺癌患者术后手术标本均行 ER 、PR 、Her-2 和ki-67 检测。根据ER 、PR 、Her-2 和ki-67 的表达情况 将乳腺癌分为四种亚型：Luminal A 型、Luminal B 型、Erb-B2 （+ ）型(即 HER-2 过表达型) 、Basal like 型(即基底样型) 。其中Luminal A 型84 例、 Luminal B 型147 例、Erb-B2 （+ ）型(即HER-2 过表达型)37 例、Basal like 型(即基底样型)35 例。另外抽取同期来我院体检的60 例患者作为对照组。 用免疫组化染色方法检测各亚型 AR(雄激素受体)表达情况，并进行比较 分析。比较NLR 、PLR 比值在各乳腺癌亚型中的变化。应用ROC 曲线，