植物乳杆菌.pptVIP

Lactobacillus plantarum?DK119 as a Probiotic Confers Protection against Influenza Virus by Modulating Innate Immunity 莫小贝 2013/11/29 Min-Kyung Park, Vu NGO, Young-Man Kwon, Young-Tae Lee, Young-Hee Cho, Sung-Moon Hong, Hye Suk Hwang, Eun-Ju Ko, Yu-Jin Jung Sieun Yoo 植物乳杆菌DK119通过调节先天免疫作为一种抗流感病毒的益生菌赋予保护 Content Abstract Introduction Result Materials and methods Summary Innovation Introduction Influenza is a serious respiratory disease, current vaccines are only effective, Antiviral medications also have limitations. Thus, it is desirable to find a more general measure that would have protective effects on influenza virus. ? Introduction Probiotics are micro-organisms which bestow health benefits on the host when administered in adequate amounts. The most common probiotics include lactic acid bacteria. Various fermented vegetables and dairy products contain a variety of lactic acid bacteria that were shown to provide health benefits and improvements to a certain level? Innovation In previous studies, the effects of lactic acid bacteria on influenza include partial survival protection or prolonged survival periods. It remains unknown whether treatments with lactic acid bacteria can confer improved protection by reducing weight loss of infected animals and thus ameliorating morbidity. Abstract In the present study, we determined whether the?Lactobacillus plantarum?DK119 (DK119) newly isolated from the fermented vegetable food “Kimchi” would confer enhanced protection against the subsequent influenza virus infection via the intranasal or oral administration. The antiviral efficacy of DK119 was evaluated by monitoring weight changes, and examining lung viral loads and histology. Materials and methods Preparation of?Lactobacillus plantarum?DK119 and Virus Virus :甲型H1N1流感A/PR8 Treatment of Mice with DK119 and Influenza Virus A/PR8 Materials and methods Female BALB/c mice DK119 (109, 108, or 107 CFU per mouse) A/PR8 H1N1 virus (2.5 LD50) Materials