银杏叶提取物包合物的制备及其显微验证.pdfVIP

第26卷第4期 河南大学学报(医学版) Vo1．26 No．4 2007年 1 1月 Journal of Henan University(Medical Science) NOV．2007 银杏叶提取物包合物的制备及其显微验证 金邻豫 ，蔡源源 ，王 博 ，唐滋贵 ，邱瑞宝 ，李建波 (1．河南大学 『匕学化工学院，河南开封475004； 2．河南大学药学院，河南开封475004) 摘 要：目的：制备银杏叶提取物13-sy．@1精包合物，以增加银杏叶提取物的水溶性，便于制剂应用。方法：用饱和 水溶液法制备银杏叶提取物包合物，并尝试采用显微镜下观察所用物料显微性状变化的方法对制备的包合物进行 了验证 、结果：制备了浅棕色粉末状银杏叶提取物包合物，通过显微镜观察，验证了包舍物的形成。结论：8 环糊 精能很好的包合黄酮类有效成分；显微镜法为一方便、直观的包合物验证方法，能够对包合物的形成进行验证。 关键词：银杏叶提取物；3-环糊精；包合物；显微镜法 中图分类号：R284．2 文献标识码：A 文章编号：1672—7606(2007j04—0026—03 Preparation of Ginko BUoba Extract I3l—cyclodextrin inclusion compounds and its identification by using microscope JIN Lin—yu ，CAI Yuan～yuan ，WANG Bo ，TANG Zi～gui ，QIU Rui—bao ，LI Jian～bo r 1．Chemistr)Chemwal Engineering College of Hen~m University,Henan Ka／feng 475004．China； 2．Pharmaceutical College of Henan University，Henan Ka ng 475004，China) Abstract：Objective： To prepare Ginko Biloba Extract··13··eyclodextrin inclusion compounds in order to increase the dissolving quality of Ginko Biloba Extract in water，and make it easy to use in preparation application．Methods： The Ginko Biloba Extract一13一cyclodextrin inclusion compounds was prepared with saturation water solution；its micro—— characteristics of the materials used in GBE inclusion compounds were identified with microscope in order tO verify whether the inclusiol1 compouflds were prepared successfully．Results： The prepared product of Ginko Biloba Extract 13一 mrclodextrin inclusion compounds is amlmr—coloured powder．The identification result is the inclusion compounds formed． Conclusion： The flavonoids are highly entrapped into 13-cyclodextrin．The identification method is a intuitional method． Key words：Ginko Biloba Extract；13-eyclodextrin；Inclusion compounds；Microscopical examination 银杏叶为银杏科植物银杏Ginkgo biloba L．的干