补充白藜芦醇对小鼠运动性骨骼肌微损伤修复的影响.pdfVIP

（5 ）与CG 组相比，EG 组小鼠运动后即刻骨骼肌ß-葡萄糖苷酸酶含量明显升高， 运动后48h 仍未恢复，ER 组骨骼肌ß- 葡萄糖苷酸酶含量与EG 组相比虽无显著性差异 （P0.05 ），但在运动后48h 已明显低于运动后即刻组 （P0.05 ）。 研究结论： （1） 一次长时间跑台运动后，小鼠骨骼肌出现较明显的损伤性变化，补充白藜芦 醇可抑制由于运动引起的骨骼肌超微结构的损伤变化。 （2 ）补充白藜芦醇可提高小鼠抗氧化能力、降低脂质过氧化反应，调节骨骼肌线 粒体Ca2+浓度，维护骨骼肌细胞结构与功能的稳定，进而起到促进EIMmD 修复的作用。 关键词：白藜芦醇 小鼠 运动性骨骼肌微损伤 IV Abstract Resveratrol is a phytoalexin produced by some plants when pathogens invade or environments worsen. Resveratrol is found in a wide variety of dietary sources including grapes, plums, peanuts, and other food products. The present study showed that resveratrol had a wide-array of biological activities, such as scavenging free radicals, effect on anti- lipid peroxidation, adjustment to Ca2+, also function to phytoestrogen etc. At present, resveratrol is concentrated mainly in the field of medicine and Pharmacology, in sports medicine is still rare. This study investigated the supplement resveratrol to promote exercise- induced skeletal muscle micro-damage repair effects and possible mechanisms, for the prevention and treatment EIMmD, and develop a new sports nutrition supplements provides theoretical and experimental basis. Methods: 70 male Kunming mice were randomly divided into three groups: control group (CG), exercise group (EG) and exercise + resveratrol group (ER), and EG group and ER group was divided into three sub- groups by post-exercise 0 hour 、24 hours、48 hours, which every group has 10 mice. The mice of ER were given resveratrol with 10 mg/kg/d, and taken protocol of treadmill training for 4-week, then had a gradient of 0 and a speed of 18m/min, continued 90min of treadmill exercise