第二军医大学学报剖析.docVIP

第二军医大学学报 巨大房间隔缺损合并肺动脉高压患儿血浆CF6含量变化 闫芳1 刘艳兵2 王军1* 张会军1 吕瑛1 董彦博1 李小兵 1( 河北医科大学第一医院心脏外科 石家庄0500312． 石家庄市第三医院脊柱外科 石家庄 050000摘要巨大房间隔缺损合并肺动脉高压患儿(coupling factor 6)含量的变化，以探讨CF6在本疾病中的作用。收集2年1月~201年月例巨大房缺合并肺动脉高压患儿年龄4个月~16个月，平均年龄9..1月；体重3.Kg~8.3Kg，平均体重6.2.1Kg；肺动脉高压的诊断依据2007年的《肺动脉高压筛查诊断与治疗专家共识》。巨大房间隔缺损合并肺动脉高压关键词：房间隔缺损；Changes of coupling factor 6 for arge atrial septal defect and pulmonary hypertension in children YAN Fang1, Liu Yan-bing2, WANG Jun1* , ZHANG Hui-jun1, LV Ying1, DONG Yan-bo1, LI Xiao-bing1 Department of Cardiac Surgery, the First Hospital of Hebei Medical University Department of spinal Surgery, the Third Hospital of Shi jia zhuang in Hebei province. 050030, China [Abstract] Objective:To explore changes of coupling factor 6 in plasma for large atrial septal defect and different pulmonary hypertension in children. Method: A total of 160 patients with large atrial septal defect and different pulmonary hypertension from January 2010 to August 2012 were retrospectively analyzed. The age of the cases ranged from 4 to 16 (mean 9.7±2.1) months. The weight ranged from 3.5 to8.3(mean 6.9±2.1)kg. pulmonary hypertension diagnosis base on pulmonary hypertension screen diagnosis and management specialist recognization. we divide three groups. Atrial septal defect without pulmonary artery hypertension is control group. Atrial septal defect with pulmonary artery hypertension but which is not the highest is A group. Atrial septal defect with the highest pulmonary artery hypertension is B group. The plasma CF6 level was determined by radio immunoassay for CF6. Result: CF6 level is 198.5?43.7pg/ml in control group, CF6 level is 167.7?89.8pg/ml in A group, CF6 level is 304.4?80.7pg/ml in B group. Control group and A group have not significant difference(P0.05). CF6 level is obviously high. The difference has statistical significance(P0.01). Conclusion: The plasma CF6 level was obviously increased in large atrial septal defect with the highest pulmonary artery hypertension. CF6