膜蛋白和药物转运.ppt

P-GLYCOPROTEIN AND DRUG TRANSPORT Michael M. Gottesman Chief, Laboratory of Cell Biology, NCI Deputy Director for Intramural Research National Institutes of Health Mechanisms of resistance to anti-cancer drugs Drug Resistance in Cancer May affect multiple drugs used simultaneously: known as multidrug resistance (MDR) Affects all classes of drugs, including newly designed targetted drugs Just as oncogene targets have been catalogued, we need to enumerate all mechanisms of drug resistance in cancer to solve this problem and circumvent resistance Ultimate Goal: To use molecular analysis of human