生物化学与分子生物学图片素材-ScienceSlide2.pptVIP

* Cholesterol Sterol Toolkit Pregnenolon Progesteron Aldosteron Cortisol Corticosterone Androstendione Testosteron Estriol 17?-Estradiol 1, 25-Dihydroxycholecalciferol Cholic acid Covalent modification of proteinsPoly(ADP ribosyl) Polymerase (PARP) Poly(ADP ribosyl)polymerase(PARP) NAD Nicotinamide Poly(ADP ribosyl)polymerase(PARP) Poly(ADP ribosyl)chain elongationand branching Nicotinamide NAD NAD DNA polymerase ? DNA polymerase ? DNA polymerase ? Oligosacharyltransferase N-glycosylation pathway in ER Mann-P-Dolichol transferases Flippase Dolichol P Dolichol P P Dolichol P P Dolichol P P Dolichol P P GlcNAc-Ptransferase GlcNActransferase Dolichol P Dolichol P P Dolichol P P GDP-Mannosyl transferases Glc-P-Dolicholtransferases Dolichol P Dolichol- pyrophofphatase Cytosol ER 40S 60S UTP CTP TMP Pyrimidine Nucleotide Interconversions UMP ATP ADP H2O UDP Nucleosidemonophosphatekinase ATP ADP Nucleosidediphosphatekinase ATP ADP CTPsynthase Ribonucleotidereductase deoxyUDP Nucleosidediphosphatephosphohydrolase deoxyUMP Thymidylatesynthase N5,N10-MethyleneTHF DHF TTP Nucleosidemonophosphatekinase Nucleosidediphosphatekinase Myo-Inositol-3-phosphateIns(3)P1 Biosynthesis and metabolism of phosphoinositides Glucose 6-pgosphate Ins(3)P1synthase Ins(3)P1phosphatase Myo-InositolIns PtdInssynthase PtdIns Myo-inositolkinase PtdIns-4-P PtdIns4-kinase PtdIns5-kinase PtdIns-4,5-P2 PI3K PtdIns-3,4,5-P3 PLC PLC PI3K PtdIns-3,4-P2 Ins-1,3,4-P3 Ins-1,3,4,5-P4 Ins-1,4,5-P3 PLC PTEN PTEN Ins-1,4-P3 PTEN PTEN Fatty acidsynthase ?-ketoacylACP-synthase Fatty acids synthesis Acetyl CoAcarboxylase ATP ADP + Pi Acetyl CoA Malonyl CoA Citrate Oxaloacetate ATP ADP + Pi Citrate lyase Acetyltransacylase Malonyltransacylase Pantetheine ?-ketoacylACP-reductase Pantetheine Pantetheine ?-hydroxyacylACP-dehydratase Pantetheine Enoyl-ACPreductase Pantetheine NADPH NADP NADPH NADP Cholesterol de novo synthesis IIsoprenyl formation Acetoacetyl-CoA Thiolase HMG-Co