母牛分枝杆菌菌苗辅助治疗复治涂阳肺结核效果观察.pdfVIP

公共卫生与预防医学2007年第l8卷第6期 J ofPubHealth and PreyMed 2007．Vo1．18。No．6 17· · 论著· 母牛分枝杆菌菌苗辅助 治疗 复治涂阳肺结核效果观察 王俊 陈红璋 李双初 【摘要】目的 评价母牛分枝杆菌菌苗作为免疫调节剂治疗复治涂阳肺结核的临床疗效与安全性。方法 采 用随机分组，82例复治涂阳肺结核患者分为治疗组(42例)和对照组(40例)，两组均采用2HRzEs／1HRZE／5HRE 方案；治疗组加用母牛分枝杆菌菌苗(微卡)每2周1次，共8个月。观察治疗后肺部病灶吸收、痰菌阴转、临床症 状缓解情况。结果 疗程结束时治疗组与对照组胸部x线病灶显著吸收率分别为83．3％和50，0％(P0．05)；空 洞闭合率分别为78．5％和52．5％(P0．05)；治疗2…4 6 8个月末痰菌阴转率治疗组为61．9％、80．9％、90．4％、 92．8％；对照组为37．5％、55．0％、67．5％、72．5％(P0．05)；疗程结束时治疗组与对照组临床症状缓解无显著差 异(P0．05)。微卡不良反应：发热1例。结论 母牛分枝杆菌菌苗辅助治疗复治涂阳肺结核，能增强免疫细胞活 性，促进肺部病灶吸收，提高痰菌阴转率，是较好的结核病免疫治疗制剂。 【关键词】结核；肺／药物治疗；母牛分枝杆菌菌苗 【中图分类号】R521 【文献标识码】A 【文章编号】1006—2483(2007)06-0017-03 Curative effect of the re·treated bacteriological positive pulmonary tuberculosis treated with Mycobacterium vaccae vaccine WANG Jun，CHEN Hong-zhang，LI Shuang—chu． Center for Tuberculosis Control in Xiaogan，Xiaogan 432000，China 【Abstract】 Objective To evaluate the clinical curative effect and safety of Mycobacterium vaccae vaccine in trea· ting re—treated bacteriological positive pulmonary tuberculosis(TB)．Methods 82 re—treated bacteriological positive pul— monary tuberculosis patients were randomly allocated into treatment group(42cases)and control group(40cases)， 2HRZES／1 HRZE／5 HRE was applied in both group，vaccae was added in the treatment group．Foci absorption、sputum negative conversion and clinical symptoms conversion were observed．Results At the end of the treatment，chest radio— graphy showed that the resolution of pulmonary lesions in the treatment group and control group were 83．3％ and 50．0％ respectively；cavity closure rate Was 78．5％ in the treatment group and 52．2％ in the control group：the sputum negative conver