淋巴结检出数对Dukes’B期及C期大肠癌患者预后的影响.pdfVIP

2007年第34卷第24期 中国肿瘤临床 ·1405· 淋巴结检出数对Dukes B期及C期大肠癌患者预后的影响 摘要 目的：探讨淋巴结检出数对Dukes B期及C期大肠癌患者预后的影响 方法：回顾分析373例 DukesB 期及C期患者的临床病理特征与淋巴结检出教的关系，及不同淋巴结检出数对患者预后的影响，结果：全纽患者淋 巴结检出数为 13 71±9．38枚，肿瘤部位、大小及肿瘤浸润深度是影响淋巴结检出数的主要因素．结肠癌患者淋巴结 检出数为17 51±12 79枚，显著多于直肠癌患者的 l1 09+6．17枚(P=O 000)：淋巴结检出较少(0～10枚)的DukeS B期 大肠癌患者，其5年生存率仅为60 4％，而淋巴结检出较多(10枚)的Dukes B期患者，其5年生存率为74，5％，两者 比较具有显著性差异( 0 002)。但淋巴结检出数对Dukes C期大肠癌患者的预后无影响(P0、05) 、将结、直肠癌患 者分别分析表明，直肠癌患者淋巴结检出数9枚，结肠癌患者淋巴结检出数13枚时，其5年生存率显著降低(P 0，05) 结论：为保证分期的准确及指导适宜的术后辅助治疗，直肠癌患者术后至少应检出9枚淋巴结，结肠癌患者至 少应检出13枚淋巴结 关键词 大肠癌 淋巴结 预后 Influence of the Number of Lymph Nodes Retrieved on the Prognosis of Colorectal Cancer Dukes Stage B and C Bi Xinyu Cai Jianqiang Zhao Jianjun et al Department of A bdominal Surgery，Cancer Hospital，Chinese A cademy of Medical Sciences，Beijing Abstract Objectives：To discuss the influence of the number of lymph nodes retrieved on the prognosis of colorectal cancer of Dukes stage B and C．Methods：Clinic0path0l0gic features of 373 patients with colorectal cancer of Dukes stage B and C were retrospectively reviewed．The relationship between the number of lymph nodes retrieved and prognosis of these patients was analyzed．Results： The mean number of recovered lymph nodes in all colorectal cancer patients was 13．71-+9．38．Tumor site，tumor size and depth of invasion influenced the number of lymph nodes retrieved．The average number of retrieved lymph nodes in colon cancer patients was 17．51±12．79；whereas in rectal cancer patients it was 1 1．09_+6．17(尸=0．000)．The 5-year survival rate for patients with fewer lymph nodes(0～ 10)retrieved was 60．4％，lower than the 77．5％for patients with more lymph nodes retrieved(≥10)． The number of lymph nodes retrieved did not affect the prognosis for