骨质量是由骨的显微结构、骨代谢转换、骨矿化程度以及骨胶原、骨 .docVIP

女性PTH、25（OH）D3、CT、骨代谢标志物与BMD相关性研究 张萌萌 李亚刚 马倩倩 高远 毛未贤 梁斌斌 刘颖 吉林大学第四医院（吉林 长春） 130011 目的：研究甲状旁腺素（PTH）、25-羟基维生素D3（25（OH）D3）、降钙素（CT）Ⅰ型胶原C端肽（CTX-1）、抗酒石酸酸性磷酸酶（TRACP）骨钙素（BGP）、骨特异性碱性磷酸酶（BALP）与股骨颈骨密度（BMD）的相关。 方PTH、25（OH）D3、CT、 Study on the relevance of PTH、25（OH）D3、CT、bone metabolism indicator with BMD female ZHANG Mengmeng, LI Yagang, MA Qianqian,GAO Yuan, MAO Weixian,LIANG Binbin,LIU Ying. The Forth Affiliated Hospital of JiLin University，Changchun 130011,Jilin,China [Abstract] Objective：To study the relevance of PTH, 25（OH）D3, CT, bone resorption markers CTX-1 and TRACP, bone formation markers BGP and BALP with the femoral neck BMD in female. Methods：Enzyme immunoassay analyzer of Thermo company to detect PTH, 25（OH）D3, CT, CTX-1, TRACP, BGP, BALP , and emoral neck BMD was measured by Discovery-WA-type bone mineral density detector of the United States Hologic company. To divide the results of 860 objects into several groups according to the standard of 5-year-old age as a group, SPSS 13.0 software was applicated for statistical analysis. Results： The measure values of PTH, 25（OH）D3 and CT had no differences in 35-50 age group . The measure values of 25（OH）D3 began to decline after the age of 50, and 25（OH）D3 had positive relevance with BMD .The measure values of CT was decreased in the age groups from 65 to 79 years old,and was significant positive correlated with BMD.The CTX-1, TRACP had negative relevance with BMD in 35-45 age group and BGP, BALP had positive relevance with BMD in 35-45 age group. The BGP, BALP increased significantly in 50-60 age group, and CTX-1、TRACP、BGP、BALP had negative relevance with BMD in 50-60 age group. BGP, BALP began to decline and had positive relevance with BMD after the age of 65, and CTX-1, TRACP had negative relevance with BMD after the age of 65. Conclusion：PTH, 25（OH）D3, CT, CTX-1, TRACP, BGP, BALP were the important technical means for monitoring the level of bone metabolism and the diagnosis and