替加环素联合头孢哌酮舒巴坦治疗多重或泛耐药鲍曼不动杆菌感染的.doc

替加环素联合头孢哌酮舒巴坦治疗多耐药鲍曼不动杆菌 邵 李良海 华中科技大学附属荆州中心医院 湖北荆州 434020 [摘要]目的：观察替加环素联合头孢哌酮舒巴坦治疗多耐药鲍曼不动杆菌的疗效。方法：多替加环素联合头孢哌酮舒巴坦结果：有统计学意义(P0.05)结论：多耐药鲍曼不动杆菌替加环素联合头孢哌酮舒巴坦治疗。 [关键词] 头孢哌酮舒巴坦；替加环素；多耐药鲍曼不动杆菌 The clinical effect of tigecycline combined with cefoperazone sulbactam in the treatment of muitidrug resistant Acinetobacter baumannii infection SHAO Feng LI Liang-hai Intensive Care Units, the Affiliated Jingzhou central hospital of Huazhong University of science and technology, Jingzhou 434020 Abstract：Objective To observe the clinical effect of tigecycline associated with cefoperazone sulbactam for treatment of caused by muiti or extensively drug-resistant Acinetobacter baumannii. Methods 45 patients infected with muiti or extensiveIy drug-resistant Acinetobacter baumannii pneumonia were analyzed from January 2013 to June 2014. The level of PCT, CRP, WBC and clinical cure rates were collected and compared before and after treatment, as well as microbiological eradication, side effect and morality. Results Patients were infected with Acinetobacter baumannii, which was charactered with muiti or extensively drug resistant. After combined treatment, the clinical effective rate, the Bacterial clearance rate and the morality rate were 55.5%, 71.4% and 12.5%, respectively. Compared with before treatment, the level of PCT, WBC and CRP was significantly decreased (P0.05). After combined treatment, the side effect rate was 17.5%，mainly the?liver function damage?and?gastrointestinal tract?reaction,?and?to a lesser degree. Conclusion Tigecycline combined cefoperazone sulbactam can be tried for the treatment of multi-drug resistant or extensively drug resistant Acinetobacter baumannii infection, but the specific?still need?further?clinical?evidence. KEY WORDS cefoperazone sulbactam; tigecycline ; muiti or extensiveIy drug resistant Acinetobacter baumannii 鲍曼不动杆菌是导致医院内感染的重要致病菌之一，其广泛分布于空气、体表、胸腔及呼吸道中，属于非发酵类革兰阴性杆菌[1]。伴有严重的基础疾病，免疫功能低下，再加上部分患者使用呼吸机、留置导管、长期卧床以及长期大量使用抗菌药物使得其成为鲍曼不动杆菌感染的易