EXT2基因多态性与南方人2型糖尿病的相关性研究.docVIP

　　EXT2基因多态性与南方人2型糖尿病的相关性研究 【摘要】 　　目的： 探讨EXT2基因多态性与2型糖尿病及其代谢指标的相关性。方法： 研究对象均来自于上海地区，其中糖尿病患者共286例，正常人300例。RFLP法检测基因位点rs3740878, r和 rs1113132的多态性。Hardyethods： A total of 286 cases ellitus(type 2 diabetes group) and 300 normal group(NC group) from Shanghai area orphisms of rs3740878, rand rs1113132 ined by polymerase chain reactionrestriction fragment length polymorphism(PCRRFLP) assay ic DNA. The genotype frequency . Meanetabolic parameters es higher than those carrying G allele(OR=1.30, 95% CI:1.017-1.665,P=0.036). As pared es increased risk of type 2 diabetes(OR=1.68, 95% CI:1.022-2.773,χ2=4.233, P=0.04). Similarly,as for rthe TT(56.7%) genotype in type 2 diabetes al(46.3%) group(χ2=18.262, Plt;0.000 1),the allele of T(74.7%) in type 2 diabetes al(65.7%) group(χ2=20.467, Plt;0.000 1). pared ozygotes(CC) the heterozygotes(CT) increases susceptibility to type 2 diabetes 1.9(OR=1.9, 95% CI:1.063-3.405, χ2=4.776, P=0.029) times and pared ozygotes(CC) the homoozygotes(TT) increases susceptibility to type 2 diabetes 2.497(OR=2.497, 95% CI:1.419-4.369, χ2=10.482, P=0.001) times. Hoetabolic parameters. In addition, there orphism betal groups. Conclusion: The A allele(rs3740878) and the T allele(r of EXT2 polymor 6 7 phism ay have nothing to do ellitus in South of China. 　　［Key orphism; EXT2 gene 　　It is reported that the total number of people ated to increase from 20.8 million in 2000 to 42.3 million in 2030［1］. Besides the important contribution of environmental factors, including changes in dietary patterns and lifestyle, geic determinants also play a major role in type 2 diabetes susceptibility. Over the past decade, serious efforts have been put into the search for type 2 diabetes susceptibility genes, but progress is sloeous single nucleotide polymorphism(SNP) in the gene for exostoses 2(EXT2; rs3740878, rsll037909 and rs 1113132)［5］. For future application of these risk alleles in the assessment of the overall diabetes risk