生物化学蛋白质部分讲解2概要1.pptxVIP

Protein Ubiquitination and Degradation;Protein Degradation Why are proteins degraded? In order to keep a cell working it needs to remove: incorrectly synthesized proteins (with errors in amino acid sequence) damaged proteins (i.e. oxidative damage) cell-cycle specific proteins other signaling proteins which are no longer necessary Protein degradation could occur in the cytoplasm, nucleus, chloroplast, mitochondria, Vacuole (lysosome) and even in the intracellular space Lysosomes are acidic vesicles that contain about 50 different enzymes involved in degradation: proteases (cathepsins):? cleav