氮酮对复方斯亚旦生发酊中苦杏仁苷的体外透皮吸收实验研究.pdfVIP

28 5 ( ) Vol. 28 No. 5 2010 10 Jo rnal of Shihezi University(Nat ral Science) Oct. 2010 :2010) 1 2 2 2 1,2 , , , , ( / , 832000) : , , Franz , , H PLC , , 4% , 2 2 15. 74 g/ ( cm h) ; ( 30 70) , 3% , 11. 26g/ ( cm h) : ; ; ; : R284. 2 :A Promotion of Amygdaloside Transdermal Absorption by Azone in Compound Siyadan Tincture 1 2 2 2 1,2 WANG Y anji , ZH AO Haijiao , LI H iling , L o Congyan , CHEN Wen ( College of Pharmacy , Shihezi University/ Key Laboratory of Xinjiang Phytomedicine Reso rces, Shihezi 832000, China) Abstract: In order to investigate the promotion effect of Azone as an additive in Compo nd Siyadan T inc t re, and find the optim m concentration to promote the transdermal absorption, w e sed Franz diff sion cell to st dy the perc taneo s absorption w ith excised rat skin. T he amo nt of Amygdaloside in the re ceived sol tion w as determined by HPLC at different time points. The optim m concentration of Azone w as 2 4% w hen the reception sol tion w as Sodi m Chloride, and the permeation rate w as 15. 74 g/ ( cm h) ; the optim m concentration w as 3% w hen the reception sol tion w as M eOHH2 O ( 30 70) , and the permeation 2 rate w as 11. 26 g/ ( cm h) . T he concl sion w as that Azone co ld effectively promote the transdermal ab sorption rate of Amygdaloside in Compo nd Siy